Department of Biotechnology, Yonsei University, Seoul, Korea
Founder and CEO
Good T Cells, Inc.
▣ Office Address
50 Yonsei-ro, SeoDaeMun-Gu
Dept. of Biotechnology,
College of Life Science and Biotechnology,
Yonsei University, Seoul, Korea, 03722
Phone : +82-2-2123-7653 (Lab)
E-mail : sjrlee@yonsei.ac.kr
▣ Education
Dept. of Biotechnology, Yonsei University, Seoul Korea (BE)
Dept of Immunology, School of Medicine, University of Michigan, Ann Arbor (M.S.)
Dept. of Immunobiology, Yale Medical School (Ph.D.)
Division of Immunology, Harvard Medical School (Postdoctoral Fellow and Research Associate)
▣ Career
1995 - Current
Professor (연세대학교 생명공학과 교수), Dept. of Biotechnology, Yonsei University
2007 - 2008
Visiting Professor to Dept. of Immunobiology, Yale Medical School, USA
2009 - 2012
Director (염증반응제어 창의연구단 단장), National Creative Research Initiatives Inflammatory Response Modulation
2014 - 2016
Dean, College of Life Science and Biotechnology (연세대학교 생명시스템대학 학장)
2014 - Current
Director (국가지정연구실, 글로벌연구실 단장) National Research Laboratory (NRL) and Global Research Laboratory (GRL)
2016 - Current
Founder and CEO of Good T Cells, Inc
▣ Awards
2003: Best Research Award From Yonsei University
2006: Best 50 Research Award From Korea Science and Engineering Foundation
▣ Major Publications
Tomohiro Morio, Silva H. Hanissian, Leonard B. Bacharier, Hirobumi
Teraoka, Shigeaki Nonoyama, Makoto Seki, Jun Kondoh, Hiroyasu Nakano, Sang-Kyou Lee.
Ku in the Cytoplasm Associates with CD40 in Human B Cells and
Translocates into the Nucleus Following Incubation with IL-4 and
Anti-CD40 mAb.
Immunity, Vol. 11, 339-348 (1999) (I.F. = 21.5)
Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Joo Chang, Wook-Jin Chae,
Duck-Jong Han, Morio Tomohiro, Jung-Jin Yang, Alfred Bothwell and Sang-Kyou Lee* (Corresponding Author)
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific Apoptosis Induction.
Proc. Natl. Acad. Sci., U.S.A. Vol 99, no. 16, 10617 - 10622 (2002) (I.F. = 10.5)
Wook-Jin Chae, Octavian Henegariu, Alfred Bothwell and Sang-Kyou Lee. (Corresponding Author)
Mutant leucine zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.
Proc. Natl. Acad. Sci., U.S.A. Vol. 103, No. 25, 9631-9636 (2006) (I.F. = 10.5)
Je-Min Choi, Mi-Hyun Ahn, Wook-Jin Chae, Yung-Gook Jung, Byung-fhy Seo, Jae-Chul Park, Kyun-Do Kim, Eun-Sung Kim, Jung-Ah Shin, Hyun-Mi Song, Young-Eun Kim, Tae-Kwann Park, Jung-Hoon Lee, Dong-Ho Lee, Seung-Kyou Lee, Choon-Sik Park and Sang-Kyou Lee. (Corresponding Author)
Intra-nasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation and hyper-responsiveness.
Nature Medicine, Vol. 12, No. 5, 574-579 (2006) (I.F. = 31.2)
Je-Min Choi, Seung-Hyung Kim, Jae-Hoon Shin, Thomas Gibson, Byoung-Seok Yoon, Dong-Ho Lee, Seung-Kyou Lee, Alfred L. M. Bothwell, Jong-Soon Lim, Sang-Kyou Lee. (Corresponding Author)
Intracellular delivery of cytoplasmic domain of CTLA-4 inhibits TcR-specific membrane proximal activation signals and prevents collagen-induced arthritis.
PNAS, vol. 105, no. 50, 19875-19880 (2008) (I.F. = 9.8)
Je-Min Choi, Jae-Hoon Shin, Myung-Hyun Sohn, Marth J. Harding, Da-Young Kim, Wook-Jin Chae, Sung-Ho Park, Chun-Geun Lee, Sang-Kyou Lee, and Alfred Bothwell (Co-coresponding Author)
Cell permeable Foxp3 protein alleviates autoimmune disease associated with IBD and allergic airway inflammation
PNAS, vol 107, no 43, 18575-18580(2010) (I.F.=9.8)
Do Jin Kim, Kang-Seo Park, Jung-Ho Kim, Sang-Hwa Yang, Ji Young Yoon, Byeong-Gu Han, Hyoun Sook Kim, Sang Jae Lee, Jun Young Jang, Kyoung Hoon Kim, Mi Jung Kim, Jin-Su Song, Hie-Joon Kim, Chung-Mo Park, Sang-Kyou Lee*, Byung Il Lee*, and Se Won Suh* (Co-corresponding author)
A Helicobacter pylori Proinflammatory Protein Is a Cell-translocating Ser/Thr Kinase for Up-regulation of NF-κB.
PNAS, vol 107, no 50, 21418-21423(2010) (I.F.=9.8)
Sang-Won Lee, Ji-Hye Kim, Min-Chan Park, Yong-Beom Park, Wook-Jin Chae, Tomohiro Morio, Dong-Ho Lee, Ki-Doo Choi, Joo-Hyung Lee, Dong-Hwan Park, Seung-Kyou Lee, Soo-Kon Lee, Sang-Kyou Lee (Corresponding author)
Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery
Biomaterials, Vol . 33, no.5, 1563-1572(2012) (I.F.=7.9)
Jae-Hyuck Shim, Matt Greenblatt, Anju Singh, Nicholas Brady, Dorothy Zhang Hu, Rebecca Drapp, Wataru Ogawa, Masato Kasuga, Tetsuo Noda, Sang-Hwa Yang, Sang-Kyou Lee, Vivienne Rebel, Laurie Glimcher
Administration of BMP2/7 in utero partially reverses Rubinstein Taybi Syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.
Journal of Clinical Investigation, Vol 122, No. 1, 91-106(2012) (I.F.=15)
Fumiko Honda, Hirotsugu Kano, Hirokazu Kanegane, Shigeaki Nonoyama, , Eun-Sung Kim, Sang-Kyou Lee, Masatoshi Takagi, Shuki Miautani and Tomohiro Morio.
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils
Nature Immunology, Vol .13, 369-378 (2012) (I.F.=25.7)
Tae-Yoon Park, Seung-Hyung Kim, Yoon-Chul Shin, Nae-Hyun Lee, Jae-Hyuck Shim, Laurie Glimcher, Eunji Cheong, Won-Ki Kim, Jong-Soon Lim and Sang-Kyou Lee (Corresponding author)
Amelioration of Alzheimer-associated neurodegeneration by cell death-induced cytoplasmic delivery of humanin
Journal of Controlled Release (2013), 166, 307-315 (I.F.=7.164)
Tae-Yoon Park, Seong-Dong Park, Jen-Young Cho, Na-Yeon Kim, Christina Rae-Kyung Lee, Sang-Hwa Yang and Sang-Kyou Lee*(Corresponding author)
Transcriptional interactomic inhibition of RORγt suppresses TH17
differentiation and autoimmunity
PNAS, vol 111, no.52, 18673-18678, (2014) (I.F.=9.8)
Jae-Seung Moon, Chin Hee Mun, Sang-Won Lee and Sang-Kyou Lee (Co-corresponding author)
Intra-nuclear delivery of transcription modulation domain of T-bet improved lupus nephritis in (NZB/NZW) F1 lupus-prone mice
Kidney International (2017) (I.F.=8.7)
▣ Manuscripts in progress
Jae-Seung Moon et al., in progress in Nature (2020) (Corresponding author)
Sung-Dong Park and Jun-Chang Hoo et al., in progress in Nat. Med. (2020) (Corresponding author)
Jung-Ho Kim and Jun-chang Hoo et al., in progress in PNAS (2020) (Corresponding author)
Bo-Young Shin et al., manuscript in preparation for Nat. Med. (2020) (Corresponding author)
